A histopathological and immunohistochemical appraisal of Plasmablastic Non-Hodgkin lymphoma

Jonathan Vaubell, Pratistadevi Ramdial


Plasmablastic lymphoma is a recently described non-Hodgkin lymphoma that occurs primarily in immunosuppresed patients.  Fewer than 100 cases have been reported in the literature, as such the histological, immunohistochemical and molecular features of these tumours are incompletely described and poorly characterized.  Plasmablastic lymphoma is well recognized as an AIDS-associated non-Hodgkin lymphoma in the Department of Anatomical Pathology.  This study therefore intends highlighting the histopathological spectrum, immunohistochemical profile and molecular attributes of the tumour in what may be the largest worldwide series to date.