Characterisation of Mycobacterium tuberculosis specific T cell functionality in HIV-infected and uninfected South African Adults

Shivan Chetty, Victoria Kasprowiicz

Abstract


MTB is the greatest cause of death in HIV infected individuals in Sub-Saharan Africa. T cells are vital for effective immune control of moninfcetd HIV/TB patients and recently the property of certain T cells to secrete multiple effector cytokines have been shown to correlate to slower disease progression and viral load. We aim to assess T cell polyfunctionality and T cell immune dysfunction pathways in HIV positive patients who progress to active TB in comparison to non-progressors. By doing this we hope to elucidate functional predictors and possible therapeutics with regard to TB progression.