AN EXPLORATION OF ANAEMIA IN LOW BIRTH WEIGHT INFANTS EXPOSED TO PERINATAL ZIDOVUDINE AT THE NEONATAL UNIT IN KING EDWARD VIII HOSPITAL

Sherika Hanley, Andrew Ross

Abstract


Large clinical trials and cohort studies beginning with the PACTG-076 and across Europe and the US demonstrate that perinatal exposure results in haematological side effects in the neonate, mainly anaemia which is clinically insignificant and reversible. No similar studies have been conducted in sub-Saharan Africa at the height of the HIV/PMTCT era. There is a scarcity of records showing figures of babies with neonatal anaemia who have had intrauterine exposure to Zidovudine and whether the anaemia is clinically significant. This study looks at medical records of 250 HIV-exposed, low-birth weight neonates admitted to the neonatal unit at King Edward VIII Hospital who have had intrauterine exposure to zidovudine, for the purpose of evaluating the prevalence and clinical significance of anaemia in our own diverse South African setting