Molecular epidemiology, drug susceptibility patterns and immunological biomarker responses to treatment of mycobacterium tuberculosis in hiv-infected and -uninfected children

Junaid Shaik, Prakash Jeena, Manormoney Pillay

Abstract


The increased prevalence of both MDR and XDR strains of MTB pose a serious threat to TB control. Genotypic diversity and its association with drug resistance in children are inadequately documented. Contact tracing is vital in order to determine transmission patterns within communities. The impact of co-infection with HIV in both adults and children in the transmission of TB has not yet been investigated. The clinical management of infected children may be improved by an early assessment of their response to treatment. A profile of several immunological markers rather than a single biomarker may be more useful in predicting treatment response outcomes