The Role of KIR Genes in Acute and Early HIV-1 Infection

Ramona Moodley, Thumbi Ndung'u


We hypothesize that KIR gene frequencies among South Africans may differ from individuals of European descent and that HIV susceptibility and disease progression among subtype C infected South Africans may be influenced by KIR genes. We further hypothesize that the influence of specific KIR genes may depend on the phase of HIV infection and changes in KIR expression may correlate with viremia. We further hypothesize that KIR genes independently (or synergistically with HLA class I) influence HIV viral evolution.