The effect of polymorphisms in HIV-1 subtype-C protease and gag on protease inhibitor drug susceptibility.

Joanah Maxoli Mdluli, Michelle Gordon


The specific objectives are summarized as follows:


  • To phenotype viruses from patients failing a PI inclusive regimen
  • To identify polymorphisms (and mutations) that influence PI failure
  • To test the effect of polymorphisms (and mutations) by site directed mutagenesis
  • To perform homology modelling to determine if and how polymorphisms (and mutations) influence the 3D structure of protease and gag