A retrospective and descriptive study of epidemiological data, clinical presentation, neurophysiological features and laboratory features of patients with Acute Inflammatory Demyelinating Polyneuropathy admitted to tertiary neurology referral centres in K

Ansuya Kasavelu Naidoo, Anand Moodley

Abstract


To undertake a retrospective review of all patients managed with a final diagnosis of Guillain Barre Syndrome (GBS) or Acute Inflammatory Demyelinating Polyneuropathy (AIDP), diagnosed at 2 tertiary referral neurology centres in Kwazulu Natal, South Africa during a time period of Jan 2004 Jan 2010. The aim of the study is to describe and compare the epidemiological profile,clinical presentation, neurophysiological and laboratory features of GBS and compare outcome amongst the sub groups of HIV positive ,HIV status unknown and HIV negative GBS patient. The study also aims to estimate the average total cost of an inpatient admitted with a final diagnosis of GBS; looking at duration of hospital stay, need for ICU management and cost of treatment with intravenous immunoglobulin. The purpose of the study is that epidemiological studies in South Africa are scanty and data describing the clinical presentation and neurophysiological features are lacking. A large retrospective South African study is required describing clinical, laboratory and neurophysiological characteristics of GBS cases. This study will aim to fill the gaps from previous studies by describing all GBS cases, mild and severe, referred to tertiary neurology referral centers in Kwazulu Natal. This retrospective and descriptive study will look at cases cross-sectionally and longitudinally to define epidemiological data, clinical presentation, antecedent associated factors, average duration from symptom onset to referral to a tertiary centre, neurophysiological values and presentation, laboratory features and outcome where available. This will be valuable in defining the spectrum of GBS, epidemiologically, clinically, and neurophysiologically and laboratory features, seen in a South African context in a larger series of patients than previously undertaken.