The utility of serum biomarkers as a predictive tool for breast disease in women presenting with a breast lump.

Prisha Naidoo, Prebashini Naidoo


The low sensitivity combined with a lack of specificity prevents the use of currently available serum biomarkers for the early detection of breast cancer.   Various biomarkers have been measured in women presenting with breast disease. Differences in concentrations have been found between patients who were postmenopausal and pre-menopausal as well as between those who were diagnosed with malignant compared with benign breast disease.  Various serum biomarkers will be measured in all women presenting with a breast lump and correlated with the outcome, thus determining the predictive value of these markers for breast disease.